Prashant Soni
AI/ML Engineer Lead AI Engineer · OrphaNova NYC/SF

Hi I'm Prashant Soni

I build and ship AI systems end-to-end, from idea to production.

Focused on LLM systems, agents, and real-world deployment.

Recent Ships:

SpaceGuard: Orbital risk intelligence 🚀. A predictive intelligence platform providing real-time satellite collision risk assessment and portfolio monitoring.

OrphaNova: The OS for orphan drug R&D 🧬. An AI-native research engine architected to accelerate therapeutic discovery for rare diseases.

Homecastr: FaceTime for real estate 🏠. A conversational video AI that transforms static property listings into interactive, agent-led experiences.

Lastline: Lastline takes a pull request and turns it into a reviewable QA video for the team. PR → QA → Video → Chat → Feedback

Experience

Lead AI Engineer · OrphaNova Jan 2026 – Present

Building OrphaNova, an AI research system for rare disease discovery. Designed a 7-stage pipeline that retrieves biomedical literature, extracts disease-gene relationships, predicts protein structures (AlphaFold2), screens drug candidates (RDKit), performs molecular docking (Chai-1), and generates publication-ready research reports.

Research Assistant · Yeshiva University Nov 2024 – Dec 2025

Developed deep learning models for cardiomegaly detection from veterinary X-rays, achieving 85.75% accuracy on 2,000+ images. Built OrphanAtlas, a rare disease research platform combining GPT-based retrieval pipelines with biomedical datasets, now used by 500+ researchers.

Received Outstanding R&D Award at the Yeshiva University Research Symposium. Featured in YU News

Projects

Featured builds, shipped and live

Other Projects

Lastline | PR → QA Review Video

Vercel × Google DeepMind Hackathon · Pull Requests · QA · Video

Turns pull requests into review-ready evidence. Generates a guided QA walkthrough of the actual product experience, stitches it into a single review video, and routes feedback back into the team loop.

Next.js · Playwright · Gemini · Vercel

Continual Learning Agents for Kalshi

Sep 2025 - Present

Continual learning agent for Kalshi prediction markets. Learns from new market data in real-time, generates trading signals, and executes trades with built-in risk controls and backtesting framework.

Kalshi · Reinforcement Learning · Backtesting · Risk Management

Agents4Science

Sep 2025 - Present

Agent-based generative AI workflows for drug repurposing research. Mines biomedical literature, extracts evidence, and generates hypotheses. Built with LLM + RAG pipelines and domain-constrained prompting to reduce hallucinations in sparse data.

LLMs · RAG · Biomedical NLP · Drug Repurposing

Multimodal Stock Price Predictor

Jun 2025

Deep learning pipeline combining LSTM time-series analysis with FinBERT sentiment from news/social media. Achieved 15% higher accuracy than single-modality models. Includes backtesting and financial metrics (Sharpe ratio, MSE, RMSE) for risk-adjusted insights.

TensorFlow · LSTM · FinBERT · Financial ML

Kaggle ConnectX RL Agent

May 2025

Built reinforcement learning agents using Q-learning, Deep Q-Networks, and Monte Carlo Tree Search. Implemented epsilon-greedy exploration and policy gradients. Secured 7th place globally (top 0.5%) through hyperparameter tuning and reward shaping.

Reinforcement Learning · DQN · MCTS · Python

GitHub Highlights

Pinned repositories from GitHub.

Education

Yeshiva University Visit

M.S. in Artificial Intelligence

Katz School of Science and Health

New York, NY · Dec 2025 · GPA 3.8/4.0

IIIT Bangalore Visit

PG Diploma in Data Science

Indian Institute of Information Technology (IIIT) Bangalore

India · Jun 2024 · GPA 3.8/4.0

Research & Publications

Top publications from ResearchGate.

Visit ResearchGate Profile

Technical Skills

Languages & Backend

Python, TypeScript/JavaScript, FastAPI, REST APIs, Node.js

AI Systems

PyTorch, TensorFlow, LLMs, RAG, agents, embeddings, multimodal, FAISS

Cloud & DevOps

AWS, GCP, Docker, CI/CD (GitHub Actions), Linux, infra automation

Data & Realtime

PostgreSQL, MongoDB, Firebase, streaming pipelines, time-series data

Frontend & Product

React, Next.js, dashboards, map/geospatial UI, Vercel

Space & Domain

Satellite tracking, conjunction/risk pipelines, orbital telemetry, SSA tooling

Schedule a Call

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Contact

Email

prashantsonibps@gmail.com psoni@mail.yu.edu

Phone

+1 551 362 9944

Location

NYC / San Francisco