Prashant Soni
AI/ML Engineer Founding Engineer · OrphaNova NYC/SF

Hi I'm Prashant Soni

I build and ship AI systems end-to-end, from idea to production.

Focused on LLM systems, agents, and real-world deployment.

Recent Ships:

SpaceGuard: Kalshi for space events 🚀. A predictive intelligence platform providing satellite collision risk assessment via real-time market signals.

Homecastr: FaceTime for real estate 🏠. A conversational video AI that transforms static property listings into interactive, agent-led experiences.

OrphaNova: The OS for orphan drug R&D 🧬. An AI-native research engine architected to accelerate therapeutic discovery for rare diseases.

Lastline: Lastline takes a pull request and turns it into a reviewable QA video for the team. PR → QA → Video → Chat → Feedback

Experience

Founding Engineer & Lead Developer · OrphaNova Nov 2025 – Present

Building OrphaNova, an AI research system for rare disease discovery. Designed a 7-stage pipeline that retrieves biomedical literature, extracts disease-gene relationships, predicts protein structures (AlphaFold2), screens drug candidates (RDKit), performs molecular docking (Chai-1), and generates publication-ready research reports.

Research Assistant · Yeshiva University Nov 2024 – Dec 2025

Developed deep learning models for cardiomegaly detection from veterinary X-rays, achieving 85.75% accuracy on 2,000+ images. Built OrphanAtlas, a rare disease research platform combining GPT-based retrieval pipelines with biomedical datasets, now used by 500+ researchers.

Received Outstanding R&D Award at the Yeshiva University Research Symposium. Featured in YU News

Projects

Featured builds, shipped and live

Other Projects

Kalshi Continual Learning Trading Bot

Sep 2025 - Present

Event-driven trading agent for Kalshi prediction markets. Learns from new market data in real-time, generates trading signals, and executes trades with built-in risk controls and backtesting framework.

Kalshi · Reinforcement Learning · Backtesting · Risk Management

Agents4Science

Sep 2025 - Present

Agent-based generative AI workflows for drug repurposing research. Mines biomedical literature, extracts evidence, and generates hypotheses. Built with LLM + RAG pipelines and domain-constrained prompting to reduce hallucinations in sparse data.

LLMs · RAG · Biomedical NLP · Drug Repurposing

Multimodal Stock Price Predictor

Jun 2025

Deep learning pipeline combining LSTM time-series analysis with FinBERT sentiment from news/social media. Achieved 15% higher accuracy than single-modality models. Includes backtesting and financial metrics (Sharpe ratio, MSE, RMSE) for risk-adjusted insights.

TensorFlow · LSTM · FinBERT · Financial ML

Kaggle ConnectX RL Agent

May 2025

Built reinforcement learning agents using Q-learning, Deep Q-Networks, and Monte Carlo Tree Search. Implemented epsilon-greedy exploration and policy gradients. Secured 7th place globally (top 0.5%) through hyperparameter tuning and reward shaping.

Reinforcement Learning · DQN · MCTS · Python

GitHub Highlights

Latest repositories from GitHub.

Education

Yeshiva University Visit

M.S. in Artificial Intelligence

Katz School of Science and Health

New York, NY · Dec 2025 · GPA 3.8/4.0

IIIT Bangalore Visit

PG Diploma in Data Science

Indian Institute of Information Technology (IIIT) Bangalore

India · Jun 2024 · GPA 3.8/4.0

Research & Publications

Top publications from ResearchGate.

Visit ResearchGate Profile

Technical Skills

Core

Python, PyTorch, TensorFlow, FastAPI

AI Systems

LLMs, RAG pipelines, agent systems, embeddings, multimodal, ClawAgents

Infra

APIs, vector DB (FAISS), basic cloud (GCP/AWS)

Schedule a Call

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Contact

Email

prashantsonibps@gmail.com psoni@mail.yu.edu

Phone

+1 551 362 9944

Location

NYC / San Francisco